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1

Inhibition of NADH oxidation by 1-methyl-4-phenylpyridinium analogs as the basis for the prediction of the inhibitory potency of novel compounds

Sergey O. Sablin, Matthew J. Krueger, Victoria L. Yankovskaya, Sergey E. Tkachenko, Alexander N. Razdolsky, Sergey O. Bachurin, Rona R. Ramsay, Thomas P. Singer

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1996

Language:

english

File:

PDF, 901 KB

english, 1996

2

Mechanism of the neurotoxicity of 1-methyl-4-phenylpyridinium (MPP)+, the toxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Thomas P. Singer, Rona R. Ramsay, K. McKeown, A. Trevor, N.E. Castagnoli Jr.

Journal:

Year:

1988

Language:

english

File:

PDF, 369 KB

english, 1988

3

Studies on the Characterization of the Inhibitory Mechanism of 4′-Alkylated 1-Methyl-4-Phenylpyridinium and Phenylpyridine Analogues in Mitochondria and Electron Transport Particles

Martin R. Gluck, Stephen K. Youngster, Rona R. Ramsay, Thomas P. Singer, William J. Nicklas

Journal:

Journal of Neurochemistry

Year:

1994

Language:

english

File:

PDF, 768 KB

english, 1994

4

Biochemical Events in the Development of Parkinsonism Induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine

Thomas P. Singer, Neal Castagnoli Jr., Rona R. Ramsay, Anthony J. Trevor

Journal:

Journal of Neurochemistry

Year:

1987

Language:

english

File:

PDF, 854 KB

english, 1987

5

Oxidation of Analogs of l-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine by Monoamine Oxidases A and B and the Inhibition of Monoamine Oxidases by the Oxidation Products

Stephen K. Youngster, Kathleen A. McKeown, Yuan-Zhen Jin, Rona R. Ramsay, Richard E. Heikkila, Thomas P. Singer

Journal:

Journal of Neurochemistry

Year:

1989

Language:

english

File:

PDF, 583 KB

english, 1989

6

Interaction of 1-Methyl-4-Phenylpyridinium Ion (MPP+) and Its Analogs with the Rotenone/Piericidin Binding Site of NADH Dehydrogenase

Rona R. Ramsay, Matthew J. Krueger, Stephen K. Youngster, Martin R. Gluck, John E. Casida, Thomas P. Singer

Journal:

Journal of Neurochemistry

Year:

1991

Language:

english

File:

PDF, 770 KB

english, 1991

7

Reactivation of NADH Dehydrogenase (Complex I) Inhibited by 1-Methyl-4-(4′-Alkylphenyl)pyridinium Analogues: A Clue to the Nature of the Inhibition Site

Matthew J. Krueger, Sergey O. Sablin, Rona Ramsay, Thomas P. Singer

Journal:

Journal of Neurochemistry

Year:

1993

Language:

english

File:

PDF, 311 KB

english, 1993

8

Dramatic Species Differences in the Susceptibility of Monoamine Oxidase B to a Group of Powerful Inhibitors

M.J. Krueger, F. Mazouz, R.R. Ramsay, R. Milcent, T.P. Singer

Journal:

Biochemical and Biophysical Research Communications

Year:

1995

File:

PDF, 307 KB

1995

9

The inhibition site of MPP+, the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine is near the Q-binding site of NADH dehydrogenase

Rona R. Ramsay, Andrzej T. Kowal, Michael K. Johnson, James I. Salach, Thomas P. Singer

Journal:

Archives of Biochemistry and Biophysics

Year:

1987

Language:

english

File:

PDF, 438 KB

english, 1987

10

The reaction sites of rotenone and ubiquinone with mitochondrial NADH dehydrogenase

Thomas P. Singer, Rona R. Ramsay

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

1994

Language:

english

File:

PDF, 469 KB

english, 1994

11

Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism

Rona R. Ramsay, James I. Salach, Jahan Dadgar, Thomas P. Singer

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 416 KB

english, 1986

12

Inhibition of NADH oxidation by pyridine derivatives

Rona R. Ramsay, Kathleen A. McKeown, Elizabeth Anne Johnson, Raymond G. Booth, Thomas P. Singer

Journal:

Biochemical and Biophysical Research Communications

Year:

1987

Language:

english

File:

PDF, 441 KB

english, 1987

13

Enhancement by tetraphenylboron of the interaction of the 1-methyl-4-phenylpyridinium ion (MPP+) with mitochondria

Rona R. Ramsay, Rolf J. Mehlhorn, Thomas P. Singer

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 516 KB

english, 1989

14

Evidence that the blockade of mitochondrial respiration by the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) involves binding at the same site as the respiratory inhibitor, rotenone

Matthew J. Krueger, Thomas P. Singer, John E. Casida, Rona R. Ramsay

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 371 KB

english, 1990

15

A new class of powerful inhibitors of monoamine oxidase A

Yuan-Zhen Jin, Rona R. Ramsay, Stephen K. Youngster, Thomas P. Singer

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 209 KB

english, 1990

16

Relation of superoxide generation and lipid peroxidation to the inhibition of NADH-Q oxidoraductase by rotenone, piericidin A, and MPP+

Rona R. Ramsay, Thomas P. Singer

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 476 KB

english, 1992

17

Mechanism of the neurotoxicity of MPTP: An update

Thomas P. Singer, Rona R. Ramsay

Journal:

Year:

1990

Language:

english

File:

PDF, 748 KB

english, 1990

18

Deficiencies of NADH and succinate dehydrogenases in degenerative diseases and myopathies

Thomas P. Singer, Rona R. Ramsay, Brian A.C. Ackrell

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

1995

Language:

english

File:

PDF, 827 KB

english, 1995

19

Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+

Rona R. Ramsay, James I. Salach, Thomas P. Singer

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 313 KB

english, 1986

20

Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP

Rona R. Ramsay, Jahan Dadgar, Anthony Trevor, Thomas P. Singer

Journal:

Year:

1986

Language:

english

File:

PDF, 412 KB

english, 1986

21

III. Bioactivation of MPTP: Reactive metabolites and possible biochemical sequelae

A.J. Trevor, N. Castagnoli Jr., P. Caldera, R.R. Ramsay, T.P. Singer

Journal:

Year:

1987

Language:

english

File:

PDF, 368 KB

english, 1987

22

COMMENTARY

Park, Gilbert, Coursin, Douglas, Ely, E. Wesley, England, Michael, Fraser, Gilles L., Mantz, Jean, McKinley, Sharon, Ramsay, Michael, Scholz, Jens, Singer, Mervyn

Journal:

Critical Care Clinics

Year:

2001

Language:

english

File:

PDF, 738 KB

english, 2001

23

[Part 2: Biological Sciences] || Reaction Site of Carboxanilides and of Thenoyltrifluoroacetone in Complex II

Rona R. Ramsay, Brian A. C. Ackrell, Christopher J. Coles, Thomas P. Singer, Gordon A. White and G. Denis Thorn

Journal:

Proceedings of the National Academy of Sciences

Year:

1981

Language:

english

File:

PDF, 926 KB

english, 1981

24

Structural Dependence of the Inhibition of Mitochondrial Respiration and of NADH Oxidase by 1-methyl-4-phenylpyridinium (MPP+) Analogs and their Energized Accumulation by Mitochondria

Rona R. Ramsay, Stephen K. Youngster, William J. Nicklas, Kathleen A. McKeown, Yuan-Zhen Jin, Richard E. Heikkila and Thomas P. Singer

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 809 KB

english, 1989

25

Stopped-flow studies on the mechanism of oxidation of N-methyl-4-phenyltetrahydropyridine by bovine liver monoamine oxidase B

Ramsay, Rona R., Koerber, Steven C., Singer, Thomas P.

Journal:

Year:

1987

Language:

english

File:

PDF, 701 KB

english, 1987

26

Oxidation of tetrahydrostilbazole by monoamine oxidase A demonstrates the effect of alternate pathways in the kinetic mechanism

Ramsay, Rona R., Sablin, Sergey O., Bachurin, Sergey O., Singer, Thomas P.

Journal:

Year:

1993

Language:

english

File:

PDF, 649 KB

english, 1993

27

Relationship of the oxidation state of the iron sulfur cluster of aconitase to activity and substrate binding

Ramsay, Rona R., Dreyer, Jean Luc, Schloss, John V., Jackson, Ronald H., Coles, Christopher J., Beinert, Helmut, Cleland, W. W., Singer, Thomas P.

Journal:

Year:

1981

Language:

english

File:

PDF, 919 KB

english, 1981

28

Structural dependence of the inhibition of mitochondrial respiration and of NADH oxidase by 1-methyl-4-phenylpyridinium (MPP+) analogs and their energized accumulation by mitochondria.

Ramsay, R. R., Youngster, S. K., Nicklas, W. J., McKeown, K. A., Jin, Y. Z., Heikkila, R. E., Singer, T. P.

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 854 KB

english, 1989

29

Reaction site of carboxanilides and of thenoyltrifluoroacetone in complex II.

Ramsay, R. R., Ackrell, B. A., Coles, C. J., Singer, T. P., White, G. A., Thorn, G. D.

Journal:

Proceedings of the National Academy of Sciences

Year:

1981

Language:

english

File:

PDF, 766 KB

english, 1981

30

Mother-Infant Attachment in Adoptive Families

Leslie M. Singer, David M. Brodzinsky, Douglas Ramsay, Mary Steir and Everett Waters

Journal:

Child Development

Year:

1985

Language:

english

File:

PDF, 479 KB

english, 1985

31

Health Improvement Project Zanzibar: a new model of healthcare delivery

Spencer, Mike, Greville-Heygate, Fiona, Singer, Ramsay, Rees, Jonathan, MacDonagh, Ruaraidh

Journal:

Trends in Urology & Men's Health

Year:

2015

Language:

english

File:

PDF, 214 KB

english, 2015

32

Molecular forms of aconitase and their interconversions

Ramsay, R R, Singer, T P

Journal:

Biochemical Journal

Year:

1984

Language:

english

File:

PDF, 1.31 MB

english, 1984

33

Mechanism-based inactivation of monoamine oxidases A and B by tetrahydropyridines and dihydropyridines

Krueger, M J, McKeown, K, Ramsay, R R, Youngster, S K, Singer, T P

Journal:

Biochemical Journal

Year:

1990

Language:

english

File:

PDF, 1.06 MB

english, 1990

34

Evidence that the inhibition sites of the neurotoxic amine 1-methyl-4-phenylpyridinium (MPP + ) and of the respiratory chain inhibitor piericidin A are the same

Ramsay, R R, Krueger, M J, Youngster, S K, Singer, T P

Journal:

Biochemical Journal

Year:

1991

Language:

english

File:

PDF, 673 KB

english, 1991

35

Inhibition of complex I by hydrophobic analogues of N -methyl-4-phenylpyridinium (MPP + ) and the use of an ion-selective electrode to measure their accumulation by mitochondria and electron-transport particles

Murphy, M P, Krueger, M J, Sablin, S O, Ramsay, R R, Singer, T P

Journal:

Biochemical Journal

Year:

1995

Language:

english

File:

PDF, 1.47 MB

english, 1995

36

The interaction of monoamine oxidases with tertiary amines

Singer, Thomas P., Ramsay, Rona R.

Journal:

Biochemical Society Transactions

Year:

1991

Language:

english

File:

PDF, 409 KB

english, 1991

37

The kinetic mechanisms of monoamine oxidases A and B

Ramsay, Rona R., Singer, Thomas P.

Journal:

Biochemical Society Transactions

Year:

1991

Language:

english

File:

PDF, 391 KB

english, 1991

38

Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria

Ramsay, R. R., Singer, T. P.

Journal:

Journal of Biological Chemistry

Year:

1986

Language:

english

File:

PDF, 391 KB

english, 1986

39

Medical Group Structural Integration May Not Ensure That Care Is Integrated, From The Patient’s Perspective

Kerrissey, Michaela J., Clark, Jonathan R., Friedberg, Mark W., Jiang, Wei, Fryer, Ashley K., Frean, Molly, Shortell, Stephen M., Ramsay, Patricia P., Casalino, Lawrence P., Singer, Sara J.

Journal:

Year:

2017

Language:

english

File:

PDF, 194 KB

english, 2017

40

Propofol: A New IV Anesthetic and Sedation Agent

Fox, L. George, Hellman, Christopher L., Lamberth, Michelle A., Singer, James Daniel, Gunning, Thomas C., Ramsay, Michael A. E.

Journal:

Baylor University Medical Center Proceedings

Year:

1990

Language:

english

File:

PDF, 1.57 MB

english, 1990

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